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IL17A antibody

38147
Review: comment rank 5 pdf
  Catalog No. Package Size Price
38147 100ul $279.00

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Description
  • Product Name IL17A antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were purified by affinity purification using immunogen.
  • Applications WB IF IHC
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total IL17A antibody.
  • Immunogen Type Recombinant Protein
  • Immunogen Description Recombinant protein of human IL17A.
  • Target Name IL17A
  • Alternative Names IL17A;CTLA8;IL-17;IL-17A;IL17;
  • Accession No. Swiss-Prot#: Q16552
    NCBI Gene ID: 3605
  • SDS-PAGE MW 18kd
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:200 - 1: 500
Immunofluorescence: 1:20 - 1:50
Immunohistochemistry: 1:100

Images
  • IL17A antibody - SAB | Signalway Antibody

    Western blot analysis of extracts of N (normal), R (retinopathy of prematurity) and V (VEGF/rho transgenic mice), using IL17A antibody.

  • IL17A antibody - SAB | Signalway Antibody

    Immunofluorescence analysis of mouse eyeball using IL17A antibody.

  • IL17A antibody - SAB | Signalway Antibody

    Immunohistochemistry of paraffin-embedded mouse kidney using IL17A antibody at dilution of 1:100

Background

IL-17A is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th17 cells, a distinct CD4+ T cell lineage (1,2). IL-17A stimulates the production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity (1,2). IL-17A is intimately involved in mucosal immunity against bacterial infections (1,3) and has a putative role in some autoimmune disorders (1,4). IL-17A effects appear to be exerted primarily through binding to the IL-17RA (5). IL-17A binding induces production of cytokines, chemokines and other proteins through activation of the Erk1/2 MAP kinase, PI3K/Akt, p38, and NF-κB pathways (3,4, 6). Phosphorylation of some Jaks and Stats has been observed.

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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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