protein_function: Inhibits IGF-mediated growth and developmental rates (Bysimilarity). IGF-binding proteins prolong the half-life of theIGFs and have been shown to either inhibit or stimulate the growthpromoting effects of the IGFs on cell culture. They alter theinteraction of IGFs with their cell surface receptors..
Insulin-like growth factor-binding protein 2(IGFBP2), also called IBP2, is a protein that in humans is encoded by the IGFBP2 gene. It is mapped to 2q35. By structural analysis, it showed that the IGFBP2 gene consists of 4 exons with 3 introns of lengths 27.0, 1.0, and 1.9 kb. IGFBP2 secreted by metastatic cells recruits endothelia by modulating IGF1 mediated activation of the IGF type-I receptor on endothelial cells. The IGFBP2,IGF1,IGF1R and GAS6,MERTK signaling pathways are regulators of cancer-mediated endothelial recruitment.