protein_function: Produced by activated macrophages, IL-1 stimulatesthymocyte proliferation by inducing IL-2 release, B-cellmaturation and proliferation, and fibroblast growth factoractivity. IL-1 proteins are involved in the inflammatory response,being identified as endogenous pyrogens, and are reported tostimulate the release of prostaglandin and collagenase fromsynovial cells..
The Interleukin 1 family is a group of 11 beta trefoil cytokines. Interleukin-1, produced mainly by blood monocytes, mediates the panoply of host reactions collectively known as acute phase response . Interleukin-1beta(IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta belongs to proinflammatory cytokines, promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1(VCAM-1) on hepatic sinusoidal endothelium(HSE).