• Product NameHuman IL1R1 ELISA Kit
• SpecificityHuman
• Crossing ReactivityThere is no detectable cross-reactivity with other relevant proteins.
• Immunogen TypeNSO,D21-T332
• Alternative Names    Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD121a; Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI; IL1R1; IL1R, IL1RA, IL1RT1;
• Accession No. P14778
• UniprotP14778
• Gene ID3554;
• Cell Localization Membrane; Single-pass type I membrane protein.Cell membrane. Secreted.

• sensitivity:10pg ml
  Detect Range:125pg ml-8000pg ml
  sample_type:cell culture supernates and serum.
  capture_antibody:monoclonal antibody from mouse
  detection_antibody:polyclonal antibody from goat
  gene_name:IL1R1
  protein_name:Interleukin-1 receptor type 1
  gene_full_name:Interleukin-1 receptor type 1
  tissue_specificity:
  sequence_similarities:Belongs to the interleukin-1 receptor family.
  tmb_incubation:20-25min
  research_category:immunology|innate immunity|cytokines|interleukins|cardiovascular|atherosclerosis|vascular inflammation|inflammatory mediators|stem cells|hematopoietic progenitors|lymphoid|t lymphocytic lineage|myeloid|dendritic cell lineage

• Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human IL1R1

protein_function: Receptor for IL1A, IL1B and IL1RN. After binding tointerleukin-1 associates with the corecptor IL1RAP to form thehigh affinity interleukin-1 receptor complex which mediatesinterleukin-1-dependent activation of NF-kappa-B, MAPK and otherpathways. Signaling involves the recruitment of adapter moleculessuch as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIRdomains of the receptor,coreceptor subunits. Binds ligands withcomparable affinity and binding of antagonist IL1RN preventsassociation with IL1RAP to form a signaling complex..
Interleukin 1 receptor, type I(IL1R1), also known as CD121a(Cluster of Differentiation 121a), is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. IL1R1 along with interleukin 1 receptor, type II(IL1R2), interleukin 1 receptor-like 2(IL1RL2), and interleukin 1 receptor-like 1(IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. This protein is a receptor for interleukin 1 alpha(IL1A), interleukin 1 beta(IL1B), and interleukin 1 receptor antagonist(IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting