• Product NameNicorandil
• Brief DescriptionInhibitors
• Purification99.44%
• Biological ActivityNicorandil(Ikorel)is potassium channel activator. It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
• Target NamePotassium Channel activator
• CAS No. 65141-46-0
• Calculated MW 211.18
• Formulation C8H9N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:[O-][N+](=O)OCCNC(=O)C1=CN=CC=C1
  Pathways:Membrane transporter/Ion channel
  Receptor:Potassium Channel
  Boling pt:456.7C?
  Melting pt:92C
  Solubility:Ethanol: 42 mg/mL (198.89 mM); Water: 17 mg/mL (80.5 mM); DMSO: 42 mg/mL (198.89 mM)
  Appearance:White Cotton Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kandabashi T, et al. Circulation. 2000 Mar 21;101(11):1319-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting