• Product NameDomperidone
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityDomperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
• Target NameDopamine Receptor antagonist
• CAS No. 57808-66-9
• Calculated MW 425.92
• Formulation C22H24ClN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:ClC1=CC2=C(C=C1)N(C1CCN(CCCN3C(=O)NC4=CC=CC=C34)CC1)C(=O)N2
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:D2; D3
  Boling pt:
  Melting pt:240-244C
  Solubility:Ethanol: 1 mg/mL (2.34 mM); DMSO: 48 mg/mL (112.69 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Freedman SB, et al. J Pharmacol Exp Ther. 1994 Jan;268(1):417-26.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting