• Product NamePazopanib
• Brief DescriptionInhibitors
• Purification98.78%
• Biological ActivityPazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.
• Target Namec-Kit inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 444731-52-6
• Calculated MW 437.52
• Formulation C21H23N7O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=NC(NC2=CC(=C(C)C=C2)S(N)(=O)=O)=NC=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; PDGFR; VEGFR1; VEGFR2; VEGFR3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 87 mg/mL warmed (198.84 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Harris PA, et al. J Med Chem. 2008, 51(15), 4632-4640.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting