• Product NameGNE-0877
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM.
• Target NameLRRK2 inhibitor
• CAS No. 1374828-69-9
• Calculated MW 339.32
• Formulation C14H16F3N7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC1=NC(NC2=CN(N=C2C)C(C)(C)C#N)=NC=C1C(F)(F)F
  Pathways:Autophagy
  Receptor:LRRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 67 mg/mL (197.45 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Estrada AA, et al. J Med Chem. 2014, 57(3), 921-936.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting