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Neurofilament Antibody

48259
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  Catalog No. Package Size Price
48259-1 50ul $260.00
48259-2 100ul $390.00

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Description
  • Product Name Neurofilament Antibody
  • Purification ProA affinity purified
  • Applications WB, ICC, IHC
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description Recombinant protein
  • Alternative Names 150kDa medium antibody
    160 kDa neurofilament protein antibody
    2 kDa neurofilament protein antibody200 kDa neurofilament protein antibody
    68 kDa neurofilament protein antibody
    AI847934 antibody
    CMT1F antibody
    CMT2CC antibody
    CMT2E antibody
    FLJ53642 antibody
    KIAA0845 antibody
    light molecular weight neurofilament protein antibody
    Micro glutamic acid-rich protein antibody
    mKIAA0845 antibody
    Nef3 antibody
    NEFH antibody
    NEFL antibody
    NEFM antibody
    Neurofilament 3 antibody
    Neurofilament heavy polypeptide 200kDa antibody
    Neurofilament heavy polypeptide antibody
    Neurofilament light polypeptide 68kDa antibody
    Neurofilament light polypeptide antibody
    Neurofilament medium polypeptide 150kDa antibody
    Neurofilament medium polypeptide antibody
    Neurofilament protein heavy polypeptide antibody
    Neurofilament protein light chain antibody
    Neurofilament protein light polypeptide antibody
    Neurofilament protein medium polypeptide antibody
    neurofilament subunit NF-L antibody
    Neurofilament triplet H protein antibody
    Neurofilament triplet L protein antibody
    Neurofilament triplet M protein antibody
    neurofilament-3 (150 kD medium) antibody
    NF-H antibody
    NF-L antibody
    NF-M antibody
    NF160 antibody
    NF165 antibody
    NF200 antibody
    NF68 antibody
    NFH antibody
    NFL antibody
    NFM antibody
    NFM_HUMAN antibody
    PPP1R110 antibody
    protein phosphatase 1, regulatory subunit 110 antibody
  • Accession No. Swiss-Prot#:P12036
  • Calculated MW 200 kDa
  • Formulation 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:50-1:200

Images
  • Neurofilament Antibody - SAB | Signalway Antibody

    48259

  • Neurofilament Antibody - SAB | Signalway Antibody

    48259

  • Neurofilament Antibody - SAB | Signalway Antibody

    48259

  • Neurofilament Antibody - SAB | Signalway Antibody

    48259

Background

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Neurofilament-H (NF-H), also known as neurofilament heavy polypeptide, and Neurofilament-L (NF-L), also known as neurofilament light polypeptide, members of the intermediate filament family, are major components of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and Actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease and Alzheimer's disease.

Regerences

1. Medina-Rodruez EM et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep 7:43545 (2017).
2. Vasconcelos DM et al. Immune response and innervation signatures in aseptic hip implant loosening. J Transl Med 14:205 (2016).

    Please let us know if you have published research using #48259 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
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