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IKK alpha Antibody

49025
Review: comment rank 5 pdf
  Catalog No. Package Size Price
49025-1 50ul $260.00
49025-2 100ul $390.00

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Description
  • Product Name IKK alpha Antibody
  • Clone No. SN06-99
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC, IP, FC
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names chuk antibody
    CHUK1 antibody
    Conserved Helix Loop Helix Ubiquitous Kinase antibody
    Conserved helix loop ubiquitous kinase antibody
    Conserved helix-loop-helix ubiquitous kinase antibody
    I Kappa B Kinase 1 antibody
    I Kappa B Kinase Alpha antibody
    I-kappa-B kinase 1 antibody
    I-kappa-B kinase alpha antibody
    IkappaB kinase antibody
    IkB kinase alpha subunit antibody
    IkBKA antibody
    IKK 1 antibody
    IKK A antibody
    IKK a kinase antibody
    IKK-A antibody
    IKK-alpha antibody
    IKK1 antibody
    IKKA antibody
    IKKA_HUMAN antibody
    Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody
    Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody
    Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody
    NFKBIKA antibody
    Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody
    Nuclear factor NF kappa B inhibitor kinase alpha antibody
    Nuclear factor NF-kappa-B inhibitor kinase alpha antibody
    Nuclear factor NFkappaB inhibitor kinase alpha antibody
    Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody
    TCF-16 antibody
    TCF16 antibody
    Transcription factor 16 antibody
  • Accession No. Swiss-Prot#:O15111
  • Calculated MW 85 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Images
  • IKK alpha Antibody - SAB | Signalway Antibody


  • IKK alpha Antibody - SAB | Signalway Antibody


  • IKK alpha Antibody - SAB | Signalway Antibody


  • IKK alpha Antibody - SAB | Signalway Antibody


Background

The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase a (IKKa), previously designated CHUK, interacts with IkB-a and specifically phosphorylates IkB-a on Ser 32 and 36, the sites that trigger its degradation. IKKa appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKa is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKa, IKKb and IKKg (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Regerences

1. Nielsen C et al. Immunodeficiency associated with a nonsense mutation of IKBKB. J Clin Immunol 34:916-21 (2014).
2. Thorne JL et al. Heterochromatin protein 1 gamma and IkB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages. Nucleic Acids Res : (2012).

    Please let us know if you have published research using #49025 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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