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Mouse Anti-Human CD274 (PD-1), Biotin Conjugated mAb

CM030
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  Catalog No. Package Size Price
CM030-1 25ug $189.00
CM030-2 100ug $598.00

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Description
  • Product Name Mouse Anti-Human CD274 (PD-1), Biotin Conjugated mAb
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. 10D7
  • Isotype Mouse IgG1, κ
  • Applications FC/ELISA
  • Species Reactivity Hu
  • Specificity This antibody recognizes human PD-L1 in Western blot and FACS.
  • Immunogen Description L929/PD-L1 transfected cells
  • Alternative Names Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1)
  • Formulation Lyophilized from a 0.2μm filtered solution in phosphate buffered saline (PBS) and reconstitute with sterile PBS .
  • Storage Store protected from light at 2-8˚C. Do not freeze. The expiration date is indicated on the vial label.
Application Details

Preparation:This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with L929/PD-L1 transfected cells). The monoclonal antibody was purified from tissue culture supernatant or ascites by protein G affinity chromatography.
Product Notices:This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 10^6 cells in a 100-?l experimental sample (per test). An isotype control should be used at the same concentration as the antibody of interest.

Product Description
B7-H1 (also known as PD-L1 or CD274) is a B7 family member and it is a ligand for PD-1 (programmed death-1, a member of the CD28 family). PD-L1 is constitutively expressed on a wide variety of immunocytes and nonhematopoietic cell types including some malignant tumors, suggesting the potential mechanism of immune evasion. The enhancement of T cell responses via blockade of PD-1/PD-L1 pathway may be a potential therapeutic strategy for tumor treatment.
    Please let us know if you have published research using #CM030 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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