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Recombinant Mouse Interleukin-36 receptor antagonist protein(IL36RN)

AP73423
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  Catalog No. Package Size Price
AP73423-1 2ug $88.00
AP73423-2 10ug $217.00
AP73423-3 250ug $901.00

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Description
  • Product Name Recombinant Mouse Interleukin-36 receptor antagonist protein(IL36RN)
  • Brief Description Recombinant Protein
  • Host Species E.Coli
  • Purification >95% as determined by SDS-PAGE and HPLC.
  • Biological Activity Measured by its ability to inhibit IL-36 induced IL-6 production by human PBMCs.
  • Immunogen Description Expression Region:3-156aa
    Sequence Info:Full Length of Mature Protein
  • Alternative Names IL-36Ra, IL-1HY1, Interleukin-1 delta, IL-1 delta, Interleukin-1 family member 5
  • Accession No. Q9QYY1
  • Calculated MW 16.9 kDa
  • Tag Info NO-tagged
  • Target Sequence VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
  • Formulation 0.2 ?m filtered PBS, pH 7.4 ,lyophilized
  • Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
    Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
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  • Recombinant Mouse Interleukin-36 receptor antagonist protein(IL36RN) - SAB | Signalway Antibody


Background
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2,IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
Regerences
PubMed ID: 11093146; 10744718; 11466363; 16141072; 17908936; 18284608; 21860022; 21965679; 12974628
Research Topic:Immunology
    Please let us know if you have published research using #AP73423 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
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