Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Nucleotide sequence of a full-length cDNA for 90KDA heat-shock protein from human peripheral blood lymphocytes.Soeda E., Yokoyama K., Yamazaki M., Akaogi K., Miwa T., Imai T.Nucleic Acids Res. 17:7108-7108(1989)
Research Topic:Neuroscience