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Recombinant Human Cyclic GMP-AMP synthase(CGAS),partial

AP74031
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  Catalog No. Package Size Price
AP74031-1 10ug $130.00
AP74031-2 50ug $186.00
AP74031-3 100ug $323.00
AP74031-4 200ug $532.00
AP74031-5 500ug $895.00
AP74031-6 1mg $1428.00

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Description
  • Product Name Recombinant Human Cyclic GMP-AMP synthase(CGAS),partial
  • Brief Description Recombinant Protein
  • Host Species E.coli
  • Purification Greater than 90% as determined by SDS-PAGE.
  • Immunogen Description Expression Region:161-522aa
    Sequence Info:Partial
  • Alternative Names Short name:cGAMP synthase Short name:cGAS Short name:h-cGAS Alternative name(s): 2'3'-cGAMP synthase Mab-21 domain-containing protein 1
  • Accession No. Q8N884
  • Calculated MW 58.3 kDa
  • Tag Info N-terminal 6xHis-SUMO-tagged
  • Target Sequence GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
  • Formulation Tris-based buffer50% glycerol
  • Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
    Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
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  • Recombinant Human Cyclic GMP-AMP synthase(CGAS),partial - SAB | Signalway Antibody


Background

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173,STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173,STING-dependent manner (PubMed:26229115).

Regerences

"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway."Sun L., Wu J., Du F., Chen X., Chen Z.J.Science 339:786-791(2013)
Research Topic:Others

    Please let us know if you have published research using #AP74031 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
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