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MPYS Antibody

24935
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24935 100ul $390.00

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Description
  • Product Name MPYS Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Affinity chromatography purified via peptide column
  • Applications ELISA WB ICC
  • Species Reactivity Hu Ms
  • Immunogen Type Peptide
  • Immunogen Description Raised against a 17 amino acid peptide near the carboxy terminus of human MPYS.
  • Target Name MPYS
  • Alternative Names MPYS, Transmembrane protein 173, TMEM173, ERIS, MITA, STING
  • Accession No. NP_938023
  • Concentration 1mg/ml
  • Formulation Supplied in PBS containing 0.02% sodium azide.
  • Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Images
  • MPYS Antibody - SAB | Signalway Antibody

    Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/mL.

  • MPYS Antibody - SAB | Signalway Antibody

    Western blot analysis of MPYS in (A) K562 and (B) Jurkat cell lysate with MPYS antibody at 1 μg/mL.

Background

MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.

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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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