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Recombinant Human Epidermal Growth Factor ( rHu EGF )

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70504 500ug $235.00

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  • Product Name Recombinant Human Epidermal Growth Factor ( rHu EGF )
  • Brief Description Recombinant Protein
  • Host Species E.coli
  • Purification > 95 % by SDS-PAGE and HPLC analyses.
  • Species Reactivity Hu
  • Biological Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb c 3T3 cells is less than 0.1 ng ml, corresponding to a specific activity of > 1.0 ⅹ 107 IU mg.
  • Endotoxin Less than 1 EU/��g of rHuEGF as determined by LAL method.
  • Target Name rHu EGF
  • Alternative Names Urogastrone, URG
  • Accession No. accession:P01133
  • Calculated MW Approximately 6.2 kDa, a singl
  • SDS-PAGE MW Sterile Filtered White lyophil
  • Formulation Lyophilized from a 0.2 ��m filtered concentrated solution in PBS, pH 7.4.
  • Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg mL. Stock solutions should be apportio
  • Storage This lyophilized preparation is stable at 2-8 ˚C, but should be kept at -20 ˚C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 ˚C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 ˚C to -70 ˚C. Avoid repeated freeze thaw cycles.
  • Recombinant Human Epidermal Growth Factor ( rHu EGF ) - SAB | Signalway Antibody

Epidermal Growth Factor (EGF) was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition, and stunting of growth when injected into newborn mice. Human EGF was isolated from urine based on its inhibitory effect on gastric secretion and named urogastrone, accordingly. EGF is prototypic of a family of growth factors that are derived from membrane-anchored precursors. All members of this family are characterized by the presence of at least one EGF structural unit (defined by the presence of a conserved 6 cysteine motif that forms three disulfide bonds) in their extracellular domain. EGF is initially synthesized as a 130 kDa precursor transmembrane protein containing 9 EGF units. The mature soluble EGF sequence corresponds to the EGF unit located proximal to the transmembrane domain. The membrane EGF precursor is capable of binding to the EGF receptor and was reported to be biologically active. Mature human EGF shares 70 % a.a. sequence identity with mature mouse and rat EGF.
1. Chevalier RL, Goyal S, Thornhill BA. 1999. J Urol, 162: 1532-6. 2. Gehm BD, McAndrews JM, Jordan VC, et al. 2000. Mol Cell Endocrinol, 159: 53-62. 3. Yang H, Sun X, Wang Z, et al. 2003. J Membr Biol, 194: 47-58. 4. Cohen S. 2008. J Biol Chem, 283: 33793-7.
    Please let us know if you have published research using #70504 so that we can cite your reference.
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