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    Application:
  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
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    Species Reactivity:
  • HuHuman
  • MsMouse 
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Products
  • Brief: Inhibitors
  • Brief: Cell signal transductionis the transmission of molecular signals via various proteins in asignaling cascade, which carries and amplifies the signal. TheJAK-STAT signaling pathwaycommunicates information from chemical signals outside of a cell to thecell nucleus, resulting in the activation of genes through a process calledtranscription. There are three key parts of JAK-STAT signaling:Janus kinases(JAKs),Signal Transducer and Activator of Transcription proteins(STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such asimmunity,cell division,cell deathandtumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions,cancers, and disorders affecting the immune system. There are 4 JAK proteins:JAK1,JAK2,JAK3andTYK2, and there are 7 STAT proteins:STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5BandSTAT6. JAK/STAT Compound Library from SAB, a unique collection of 145 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

PF-477736

(S6028)
  • Brief: Inhibitors
  • Brief: Inhibitors
  • Brief: Inhibitors
  • Brief: Inhibitors
  • Brief: Inhibitors
  • Brief: Inhibitors
  • Brief: Inhibitors

Curcumin

(S1516)
  • Brief: Inhibitors
Total 4983 results [1] 2 [3] [4] [5] [6] [7] [8] [9] [10] ...Last
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