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CREBBP Antibody

36778
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  Catalog No. Package Size Price
36778 100ul $279.00

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Description
  • Product Name CREBBP Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antigen affinity purification.
  • Applications IHC
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous levels of total CREBBP protein.
  • Immunogen Type Peptide
  • Immunogen Description Synthetic peptide corresponding to a region derived from internal residues of human CREB binding protein
  • Target Name CREBBP
  • Alternative Names CBP; RSTS; KAT3A
  • Accession No. Swiss-Prot#: Q92793
    NCBI Gene ID: 1387
    Gene Accssion: NP_004371
  • Concentration 0.4mg/ml
  • Formulation Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
  • Storage Store at -20˚C
Application Details

Immunohistochemistry: 1:5-1:20

Images
  • CREBBP Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36778 at dilution 1/5.

  • CREBBP Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #36778 at dilution 1/5.

Background
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Please let us know if you have published research using #36778 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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