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Tau(Phospho-Ser396) Antibody #11102

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
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Description
  • Product NameTau(Phospho-Ser396) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at serine396.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of serine 396 (Y-K-S(p)-P-V) derived from Human Tau.
  • Target NameTau
  • ModificationPhospho
  • Alternative Names    MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Accession No. Swiss-Prot: P10636
    NCBI Protein: NP _001116538.1
  • UniprotP10636
  • Gene ID4137;
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficitsInAging (Albany NY)On2023 Dec 12byLing Lei?1?2,?Yong Luo et al..PMID:?38095632, , (2023),
PMID: 38095632
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. In Int J Mol Sci on 2022 Dec 17 by Ling Lei, Jun Feng,et al..PMID:36555780, , (2022),
PMID: 36555780
Stimulation of hair growth by Tianma Gouteng decoction: Identifying mechanisms based on chemical analysis, systems biology approach, and experimental evaluation.In Front Pharmacol on 2022 Dec 16 by Yanyan Zhang, Shiqian Zhang, et al..PMID: 36588691, , (2022),
PMID: 36588691
Yuan?zhi?san inhibits tau protein aggregation in an Aβ1?40?induced Alzheimer's disease rat model via the ubiquitin?proteasome system. In Mol Med Rep on 2021 Apr by Bin Li, Pei-Jun Xie,et al..PMID:33604685, , (2021),
PMID: 33604685
View All Published Papers A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. In Theranostics on 2021 Mar 11 by Weijin Wang, Qiuzhi Zhou, et al..PMID:33859747, , (2021),
PMID: 33859747
14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments., , (2021),
PMID:
Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology. In Prog Neurobiol on 2021 Nov by Maria Rosaria Tropea, Domenica D Li Puma,et al..PMID:34453977, , (2021),
PMID: 34453977
A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. In Signal Transduct Target Ther on 2021 Jul 14 by Jie Zheng, Na Tian et al..PMID:34262014, , (2021),
PMID: 34262014
Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. In FASEB J on 2020 Dec by Ying Zhou, Dichen Yang, et al..PMID:33070372, , (2020),
PMID: 33070372
Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway. In Aging Dis on 2020 Jul 23 by Xia Zhao, Shuai Li,et al..PMID:32765947, , (2020),
PMID: 32765947
Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. In Transl Psychiatry on 2020 Jul 13 by Jun Wang, Bin-Lu Sun,et al..PMID:32661266, , (2020),
PMID: 32661266
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. In Autophagy on 2020 Apr by Qiong Feng, Yu Luo, et al..PMID:31223056, , (2020),
PMID: 31223056
Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. In Cell Stem Cell on 2020 Mar 5 by Jie Zheng, Hong-Lian Li,et al..PMID:31978364, , (2020),
PMID: 31978364
Expression of β-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats .In Clin Exp Nephrol.On 2018 Dec by Terada N, Karim MR et al..PMID:29802483 , , (2019),
PMID: 29802483
HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas.In Gynecol Oncol.On 2018 Sep by Galindo LJ, Hernndez-Beeftink T et al..PMID:30017537, , (2019),
PMID: 30017537
Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury �C via endothelial nitric oxide synthase pathway regulation .In Int J Neurosci. On 2018 Dec by Zhao H, Liu Y et al..PMID:29883225 , , (2018),
PMID: 29883225
EphrinB2 signaling enhances osteogenic/odontogenic differentiation of human dental pulp stem cells.In Arch Oral Biol. 2018 Mar by Heng BC, Wang S et al..PMID: 29272761, , (2018),
PMID: 29272761
Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model.In J Pharm Pharmacol.On 2018 Jan by Gong YH, Hua N et al..PMID: 28994117 , , (2018),
PMID: 28994117
Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model.In J Pharm Pharmacol.On 2018 Jan by Gong YH, Hua N et al..PMID: 28994117 , , (2018),
PMID: 28994117
Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development.In J Nutr Biochem. On 2018 Jul by Tian Y, Xu Q et al..PMID:29694938, , (2018),
PMID: 29694938
Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury �C via endothelial nitric oxide synthase pathway regulation .In Int J Neurosci. On 2018 Dec by Zhao H, Liu Y et al..PMID:29883225 , , (2018),
PMID: 29883225
Metformin reverses stem cell?like HepG2 sphere formation and resistance to sorafenib by attenuating epithelial?mesenchymal transformation.In Mol Med Rep.On 2018 Oct by Feng Y, Guo X et al..PMID:30106125, , (2018),
PMID: 30106125
Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
Peritoneal Dialysis Reduces Amyloid-Beta Plasma Levels in Humans and Attenuates Alzheimer-associated Phenotypes in an APP/PS1 Mouse Model.In Acta Neuropathol on 2017 Aug by Wang-Sheng Jin, Lin-Lin Shen,et al..PMID: 28477083, , (2017),
PMID: 28477083
Expression of P301L-hTau in Mouse MEC Induces Hippocampus-Dependent Memory Deficit.In Sci Rep on 2017 Jun 20 by Xinghua Liu, Kuan Zeng,et al..PMID: 28634382, , (2017),
PMID: 28634382
Sex dimorphism profile of Alzheimer's disease-type pathologies in an APP/PS1 mouse model.In Neurotox Res on 2016 Feb by Shu-Sheng Jiao, Xian-Le Bu et al..PMID:26707129, , (2016),
PMID: 26707129
Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease.In Transl Psychiatry on 2016 Oct 4 by S-S Jiao , L-L Shen et al..PMID:27701410 , , (2016),
PMID: 27701410
Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol.In J Alzheimers Dis on 2014 by Meifeng Yang, Junye Miao et al..PMID: 24787917, , (2016),
PMID: 24787917
Extrasynaptic NMDA Receptor-Induced Tau Overexpression Mediates Neuronal Death Through Suppressing Survival Signaling ERK Phosphorylation.In Cell Death Dis on 2016 Nov 3 by Xu-Ying Sun , Qing-Zhang Tuo et al..PMID: 27809304, , (2016),
PMID: 27809304
Impairment of rat spatial learning and memory in a new model of cold water-induced chronic hypothermia: implication for Alzheimer's disease.In Neurotox Res on 2015 Aug by Mohammad Mahdi Ahmadian-Attari, Leila Dargahi et al..PMID:25782579, , (2015),
PMID: 25782579
Zinc binds to and directly inhibits protein phosphatase 2A in vitro.In Neurosci Bull.On 2015 Jun by Xiong Y, Luo DJ et al..PMID:25854679 , , (2015),
PMID: 25854679
Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease. In Acta Neuropatholon 2015 Oct by Yang Xiang, Xian-Le Bu,et al..PMID:26363791, , (2015),
PMID: 26363791
Chronic Cold-Water-Induced Hypothermia Impairs Memory Retrieval and Nepeta Menthoides as a Traditional "Hot" Herb Reverses the Impairment.In Iran J Pharm Res on Winter 2014 by Mohammad Mahdi ,Ahmadian-Attar et al..PMID:24711845, , (2014),
PMID: 24711845
Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit.In J Alzheimers Dis on 2014 by Xinghua Liu , Zhihong Wang et al..PMID:24448782, , (2014),
PMID: 24448782
Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell. In PLoS One on 2013 Oct 18 by Xiaoxing Si, Wen Chen, et al..PMID: 24204656, , (2013),
PMID: 24204656
FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. In PLoS One on 2013 Nov 4 by Xiu-Qi Bao, Ning Li, et al..PMID: 24223757, , (2013),
PMID: 24223757
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.In J Neurochem on 2012 Jan by Chen LM, Xiong YS,et al..PMID:21496024, , (2012),
PMID: 21496024
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). In J Biol Chem on 2012 Mar 30 by Xu-Ying Sun, Yu-Ping Wei, et al..PMID: 22334661 , , (2012),
PMID: 22334661
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.In J Neurochem on 2012 Jan by Chen LM, Xiong YS,et al..PMID:21496024, , (2012),
PMID: 21496024
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). In J Biol Chem on 2012 Mar 30 by Xu-Ying Sun, Yu-Ping Wei, et al..PMID: 22334661 , , (2012),
PMID: 22334661
Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.In Eur J Anaesthesiol on 2010 Sep by Tan W, Cao X, et al..PMID:20485178, , (2010),
PMID: 20485178
Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats.In Clin Exp Pharmacol Physiol on 2010 Oct by Tan WF, Cao XZ,et al..PMID:20659131, , (2010),
PMID: 20659131
Please let us know if you have published research using #11102 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep