protein_function: Chemotactic for neutrophil granulocytes. Signals throughbinding and activation of its receptors (CXCR1 and CXCR2). Inaddition to its chemotactic and angiogenic properties, it hasstrong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 andCXCL7)..
Chemokine(C-X-C motif) ligand 6(CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2(GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.