protein_function: Chemotactic factor that attracts monocytes, lymphocytes,basophils and eosinophils. May play a role in neoplasia andinflammatory host responses. This protein can bind heparin. Theprocessed form MCP-2(6-76) does not show monocyte chemotacticactivity, but inhibits the chemotactic effect most predominantlyof CCL7, and also of CCL2 and CCL5 and CCL8..
Chemokine(C-C motif) ligand 8, also known as monocyte chemoattractant protein 2(MCP-2), is a protein that in humans is encoded by the CCL8 gene. CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. Monocyte chemotactic protein 2(MCP-2) is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes.