protein_function: Cytokine that plays an essential role in the regulationof survival, proliferation and differentiation of hematopoieticprecursor cells, especially mononuclear phagocytes, such asmacrophages and monocytes. Promotes the release of proinflammatorychemokines, and thereby plays an important role in innate immunityand in inflammatory processes. Plays an important role in theregulation of osteoclast proliferation and differentiation, theregulation of bone resorption, and is required for normal bonedevelopment. Required for normal male and female fertility.Promotes reorganization of the actin cytoskeleton, regulatesformation of membrane ruffles, cell adhesion and cell migration.Plays a role in lipoprotein clearance..
M-CSF, also called CSF1, has a role in development of the placenta. Uterine CSF1 concentration is regulated by a synergistic action of estradiol and progesterone. CSF1 is produced by uterine glandular epithelial cells. It had been found that FMS, the CSF1 receptor, is expressed in placenta and choriocarcinoma cell lines1. The CSF1 gene is mapped to 1p21-p13 and contains 10 exons and 9 introns spanning 20 kb2. And there are 2 forms of CSF1, with 224 and 522 amino acids, resulting from alternative splicing3.