protein_function: Monokine with inflammatory and chemokinetic properties.Binds to CCR5. One of the major HIV-suppressive factors producedby CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependentinhibition of different strains of HIV-1, HIV-2, and simianimmunodeficiency virus (SIV). The processed form MIP-1-beta(3-69)retains the abilities to induce down-modulation of surfaceexpression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also aligand for CCR1 and CCR2 isoform B..
Chemokine(C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. the CCL4 gene was assigned to a slightly more distal location: 17q21-q23 rather than 17q11-q21.