protein_function: Signal-transducing molecule. The receptor systems forIL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 forinitiating signal transmission. Binds to IL6,IL6R (alpha chain)complex, resulting in the formation of high-affinity IL6 bindingsites, and transduces the signal. Does not bind IL6. May have arole in embryonic development.
GP130(Glycoprotein 130) also known as IL6ST or CD130, is a transmembrane protein which is the founding member of the class of all cytokine receptors. The GP130 gene is mapped on 5q11.2. Gp130 showed an apparent molecular mass of 130 kD by SDS-PAGE. Gp130 is involved in the formation of high-affinity IL6-binding sites and in IL6 signal transduction. Sgp130 has a role in modulating signals transduced by membrane-bound gp130. Gp130 is an important part of many different types of signaling complexes.Gp130 molecules with mutations in either of these segments could not transduce a growth signal.