protein_function: Cytokine that in its homotrimeric form binds toTNFRSF1A,TNFR1, TNFRSF1B,TNFBR and TNFRSF14,HVEM. In itsheterotrimeric form with LTB binds to TNFRSF3,LTBR. Lymphotoxin isproduced by lymphocytes and cytotoxic for a wide range of tumorcells in vitro and in vivo.
Tumor necrosis factor-beta(TNF-beta), previously called lymphotoxin-alpha(LTA), is a cytokine produced by lymphocytes. TNF-alpha and TNF-beta share 35% identity and 50% homology in the amino acid sequence. The substance LTA mediates a wide variety of inflammatory, immunostimulatory, and antiviral responses. LTA is associated with susceptibility to myocardial infarction, asthma and other diseases. The LTA gene is located on human chromosome 6. The standard product used in this kit is recombinant protein, consisting of 172 amino acids with the molecular mass of 18.8KDa.