protein_function: Growth factor active in angiogenesis, and endothelialcell growth, stimulating their proliferation and migration andalso has effects on the permeability of blood vessels. Mayfunction in angiogenesis of the venous and lymphatic vascularsystems during embryogenesis, and also in the maintenance ofdifferentiated lymphatic endothelium in adults. Binds andactivates VEGFR-2 (KDR,FLK1) and VEGFR-3 (FLT4) receptors..
Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC. The protein encoded by this gene is a member of the platelet-derived growth factor,vascular endothelial growth factor(PDGF,VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D(VEGF-D). The C terminus of VEGFC has cysteine-rich repeat units characteristic of the Balbiani ring 3 protein(BR3P) of the midge Chironomus tentans.1,2 The standard product used in this kit is recombinant human VEGF-C, consisting of 135 amino acids with the molecular mass of 23Kda after glycosylation.