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Human APP ELISA Kit #EK5262

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Catalog No. Package Size Price Quantity
EK5262 96T $599.00
Availability:one week
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Description
  • Product NameHuman APP ELISA Kit
  • SpecificityHuman
  • Crossing ReactivityThere is no detectable cross-reactivity with other relevant proteins.
  • Immunogen TypeNSO,L18-L688
  • Alternative Names    Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); C31; APP; A4, AD1;
  • Accession No. P05067
  • Cell Localization Membrane; Cell surface proteinthat rapidly becomes internalized via clathrin-coated pits. Duringmaturation, the immature APP (N-glycosylated in the endoplasmicreticulum) moves to the Golgi complex where complete maturationoccurs (O-glycosylated and sulfated). After alpha-secretasecleavage, soluble APP is released into the extracellular space andthe C-terminal is internalized to endosomes and lysosomes. SomeAPP accumulates in secretory transport vesicles leaving the lateGolgi compartment and returns to the cell surface. Gamma-CTF(59)peptide is located to both the cytoplasm and nuclei of neurons. Itcan be translocated to the nucleus through association with APBB1(Fe65). Beta-APP42 associates with FRPL1 at the cell surface andthe complex is then rapidly internalized. APP sorts to thebasolateral surface in epithelial cells. During neuronaldifferentiation, the Thr-743 phosphorylated form is located mainlyin growth cones, moderately in neurites and sparingly in the cellbody. Casein kinase phosphorylation can occur either at the cellsurface or within a post-Golgi compartment. Associates with GPC1in perinuclear compartments. Colocalizes with SORL1 in a vesicularpattern in cytoplasm and perinuclear regions.
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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep