protein_function: Chemotactic factor that attracts skin-associated memoryT-lymphocytes. May play a role in mediating homing of lymphocytesto cutaneous sites. May play a role in cell migration duringembryogenesis. Nuclear forms may facilitate cellular migration byinducing cytoskeletal relaxation. Binds to CCR10.
Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family, it is also known under the names IL-11 R-alpha-locus chemokine (ILC), Skinkine, ESkine and Cutaneous T-cell-attracting chemokine (CTACK). The human gene is mapped to 9p13.3. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediatedinflammation of the skin. And CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotacticeffects by binding to the chemokine receptor CCR10.