protein_function: In concert with LBP, binds to monomericlipopolysaccharide and delivers it to the MD-2,TLR4 complex,thereby mediating the innate immune response to bacteriallipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leadingto NF-kappa-B activation, cytokine secretion and the inflammatoryresponse. Up-regulates cell surface molecules, including adhesionmolecules (By similarity)..
CD14, Cluster of differentiation 14, ingle-copy gene encoding 2 protein forms: a 50- to 55-kD glycosylphosphatidylinositol-anchored membrane protein(mCD14) and a monocyte or liver-derived soluble serum protein(sCD14) that lacks the anchor. By in situ hybridization and study of somatic cell hybrid DNA that the gene is located at bands 5q23-q31. CD14 acts as a co-receptor(along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide(LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein(LBP). Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns.