protein_function: Binds to collagen, thrombospondin, anionic phospholipidsand oxidized low-density lipoprotein (oxLDL). May function as acell adhesion molecule. Directly mediates cytoadherence ofPlasmodium falciparum parasitized erythrocytes. Binds long chainfatty acids and may function in the transport and,or as aregulator of fatty acid transport. Receptor for thombospondins,THBS1 AND THBS2, mediating their antiangiogenic effects. As acoreceptor for TLR4-TLR6 heterodimer, promotes inflammation inmonocytes,macrophages. Upon ligand binding, such as oxLDL oramyloid-beta 42, rapidly induces the formation of a heterodimer ofTLR4 and TLR6, which is internalized and triggers inflammatoryresponse, leading to NF-kappa-B-dependent production of CXCL1,CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5cytokine, via TICAM1 signaling pathway, as well as IL1B secretion..
CD36(Cluster of Differentiation 36) is an integral membrane protein found on the surface of many cell types in vertebrate animals and is also known as FAT, SCARB3, GP88, glycoprotein IV(gpIV) and glycoprotein IIIb(gpIIIb). The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin. The use of a CD36 genomic probe has allowed the localization of the CD36 locus to the 7q11.2 band by fluorescence in situ hybridization coupled with GTG-banding. CED-1,SCARF1 and C03F11.3,CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.