protein_function: Receptor that mediates the recognition, internalizationand degradation of oxidatively modified low density lipoprotein(oxLDL) by vascular endothelial cells. OxLDL is a marker ofatherosclerosis that induces vascular endothelial cell activationand dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDLinduces the activation of NF-kappa-B through an increasedproduction of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitricoxide (NO) release, monocyte adhesion and apoptosis. In additionto binding oxLDL, it acts as a receptor for the HSP70 proteininvolved in antigen cross-presentation to naive T-cells indendritic cells, thereby participating in cell-mediated antigencross-presentation. Also involved in inflammatory process, byacting as a leukocyte-adhesion molecule at the vascular interfacein endotoxin-induced inflammation. Also acts as a receptor foradvanced glycation end (AGE) products, activated platelets,monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria..
LOX-1(lectin-type oxidized LDL receptor 1) also known as OLR1, is a protein that in humans is encoded by the OLR1 gene. LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. The LOX1 gene is mapped to 12p13-p12 by fluorescence in situ hybridization. LOX1 is expressed on the plasma membrane of differentiated macrophages, but not on monocytes. The LOX1 protein acts as a macrophage scavenger receptor. LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.