protein_function: Cell adhesion molecule which is required for leukocytetransendothelial migration (TEM) under most inflammatoryconditions. Tyr-679 plays a critical role in TEM and is requiredfor efficient trafficking of PECAM1 to and from the lateral borderrecycling compartment (LBRC) and is also essential for the LBRCmembrane to be targeted around migrating leukocytes. Preventsphagocyte ingestion of closely apposed viable cells bytransmitting "detachment" signals, and changes function onapoptosis, promoting tethering of dying cells to phagocytes (theencounter of a viable cell with a phagocyte via the homophilicinteraction of PECAM1 on both cell surfaces leads to the viablecell"s active repulsion from the phagocyte. During apoptosis, theinside-out signaling of PECAM1 is somehow disabled so that theapoptotic cell does not actively reject the phagocyte anymore. Thelack of this repulsion signal together with the interaction of theeat-me signals and their respective receptors causes theattachment of the apoptotic cell to the phagocyte, thus triggeringthe process of engulfment). Modulates BDKRB2 activation (Bysimilarity). Induces susceptibility to atherosclerosis..
PECAM-1 is an important target GP in DITP.1 Platelet,endothelial cell adhesion molecule-1(PECAM-1) is a 130-kD member of the Ig gene superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and selective T-cell subsets.2 Platelet endothelial cell adhesion molecule-1(PECAM-1,CD31) is a member of the immunoglobulin(Ig) superfamily that has distinctive features of an immunoreceptor based upon its genomic structure and the presence of intrinsic immunoreceptor tyrosine inhibitory motifs(ITIMs) in its ligand binding polypeptide.3 PECAM-1 has recently been shown to contain functional immunoreceptor tyrosine-based inhibitory motifs(ITIMs) within its cytoplasmic domain, and co-ligation of PECAM-1 with the T-cell antigen receptor(TCR) results in tyrosine phosphorylation of PECAM-1, recruitment of Src homology 2 domain-containing protein tyrosine phosphatase-2(SHP-2), and attenuation of TCR-mediated cellular signaling.4 The standard used in this kit is the product of gene recombinant expression(extracellular part), consisting of 563 amino acids(E28-K590) with the molecular weight of 65.5KDa. After glycosylating, its molecular weight changes to 91-100KDa.