protein_function: Key component of innate and adaptive immunity. TLRs(Toll-like receptors) control host immune response againstpathogens through recognition of molecular patterns specific tomicroorganisms. TLR3 is a nucleotide-sensing TLR which isactivated by double-stranded RNA, a sign of viral infection. Actsvia the adapter TRIF,TICAM1, leading to NF-kappa-B activation,IRF3 nuclear translocation, cytokine secretion and theinflammatory response..
Toll-like receptor 3(TLR3) also known as CD283(cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. The TLR3 gene was mapped to chromosome 4q35 by fluorescence in situ hybridization. TLR3 specifically recognizes double-stranded RNA(dsRNA) and induces multiple intracellular events responsible for innate antiviral immunity against a number of viral infections.