protein_function: Receptor for interleukin-33 (IL-33), its stimulationrecruits MYD88, IRAK1, IRAK4, and TRAF6, followed byphosphorylation of MAPK3,ERK1 and,or MAPK1,ERK2, MAPK14, and MAPK8(By similarity). Possibly involved in helper T-cell function..
Interleukin 1 receptor-like 1, also known as IL1RL1 or ST2, is a protein that in humans is encoded by the IL1RL1 gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. TL1RL1 is necessary for endotoxin tolerance and, by inhibiting TLR responses, enhances Th2 responses. This gene, interleukin 1 receptor, type I(IL1R1), interleukin 1 receptor, type II(IL1R2) and interleukin 1 receptor-like 2(IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.