protein_function: Monokine with inflammatory, pyrogenic and chemokineticproperties. Circulates at high concentrations in the blood ofhealthy animals. Binding to a high-affinity receptor activatescalcium release in neutrophils. It also inhibits colony formationof bone marrow myeloid immature progenitors.
Chemokine(C-C motif) ligand 9(CCL9), also called MIP-1 gamma and MRP-2, is a small cytokine belonging to the CC chemokine family. CCL9 which found around Peyer"s patches is secreted by follicle-associated epithelium(FAE), and it can attract dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1. CCL9 is constitutively expressed in macrophages and myeloid cells. CCL9 can activate osteoclasts through its receptor CCR1(the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption.