• Product NameMouse CD32,FCGR2b,c ELISA Kit
• SpecificityMouse
• Crossing ReactivityThere is no detectable cross-reactivity with other relevant proteins.
• Immunogen TypeNSO,T40-R217
• Alternative Names    Low affinity immunoglobulin gamma Fc region receptor II; Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Lymphocyte antigen 17; Ly-17; CD32; Fcgr2; Fcgr2b, Ly-17;
• Accession No. P08101
• UniprotP08101
• Gene ID14130;
• Cell Localization Cell membrane; Single-pass type I membraneprotein.

• sensitivity:10pg ml
  Detect Range:31.2pg ml-2000pg ml
  sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
  capture_antibody:monoclonal antibody from rat
  detection_antibody:polyclonal antibody from goat
  gene_name:FCGR2B
  protein_name:Low affinity immunoglobulin gamma Fc region receptor II-b
  gene_full_name:Low affinity immunoglobulin gamma Fc region receptor II
  tissue_specificity: Widely expressed by cells of hemopoieticorigin. The isoforms are differentially expressed. Isoform IIB1 ispreferentially expressed by cells of the lymphoid lineage isoformIIB2 by cells of the myeloid lineage and isoform IIB3 is releasedby macrophages and is present in the serum. Isoform IIB1" isexpressed in myeloid and lymphoid cell lines in normal spleencells and in resting or LPS-activated B-cells but is not detectedin mesenteric lymph node cells.
  sequence_similarities:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  tmb_incubation:20-25min
  research_category:immunology|immunoglobulins|receptors|stem cells|hematopoietic progenitors|lymphoid|b lymphocytic lineage|t lymphocytic lineage|myeloid|monocytic lineage|mast cell lineage

• Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse CD32,FCGR2b,c

protein_function: Receptor for the Fc region of complexed immunoglobulinsgamma. Low affinity receptor. Involved in a variety of effectorand regulatory functions such as phagocytosis of antigen-antibodycomplexes from the circulation and modulation of antibodyproduction by B-cells. Isoform IIB1 and isoform IIB1" form capsbut fail to mediate endocytosis or phagocytosis. Isoform IIB2 canmediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cellreceptors for AG (BCR), T-cell receptors for AG (TCR), and Fcreceptors, respectively.
CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting