protein_function: The membrane-bound isoform 1 is a receptor involved inthe development of the cardiovascular system, in angiogenesis, inthe formation of certain neuronal circuits and in organogenesisoutside the nervous system. It mediates the chemorepulsantactivity of semaphorins. It binds to semaphorin 3A, The PLGF-2isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B.Coexpression with KDR results in increased VEGF-165 binding to KDRas well as increased chemotaxis. It may regulate VEGF-inducedangiogenesis.
NRP1(Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.