protein_function: Suppressor of innate inflammatory and immune responsesinvolved in curbing excessive inflammation. This function requiresSMAD3. Suppresses, or reduces, proinflammatory cytokineproduction, including IL1A and IL6, as well as CCL12, CSF1, CSF2,CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatorycytokines. Inhibits dendritic cell activation..
Interleukin 37(IL-37) also named IL1F7, is a protein that in humans is encoded by the IL1F7 gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. And it is mapped to 2q13. In vitro expression analysis showed that IL-37 was a secretory protein. And IL-37 could play an important role in the link between innate and adaptive immunity and may be useful for tumor immunotherapy. Meanwhile, IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. In addition, IL-37 can emerged as a dual-function cytokine with intra- and extracellular properties for suppressing innate inflammation. Furthermore, IL-37 is a new anti-inflammatory cytokine that plays an important role in protecting against tissue injury during infections via limiting immune and inflammatory reactions.
