protein_function: Has a role in both cell adhesion by acting as anadhesion receptor for THBS1 on platelets, and in the modulation ofintegrins. Plays an important role in memory formation andsynaptic plasticity in the hippocampus (By similarity). Receptorfor SIRPA, binding to which prevents maturation of immaturedendritic cells and inhibits cytokine production by maturedendritic cells. Interaction with SIRPG mediates cell-celladhesion, enhances superantigen-dependent T-cell-mediatedproliferation and costimulates T-cell activation. May play a rolein membrane transport and,or integrin dependent signaltransduction. May prevent premature elimination of red bloodcells. May be involved in membrane permeability changes inducedfollowing virus infection..
CD47 (Cluster of Differentiation 47), also known as integrin associated protein (IAP), is a transmembrane protein that in humans is encoded by the CD47 gene. It belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP??). CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. Also CD47 is ubiquitously expressed in human cells and has found to be overexpressed in many different tumor cells.
