protein_function: Binds EGFR, the EGF receptor, inducing EGFRautophosphorylation and the activation of downstream signalingpathways. May play a role in cell adhesion and migration. Mayfunction as a negative regulator of chondrocyte differentiation.In the olfactory epithelium, it may regulate glial cell migration,differentiation and the ability of glial cells to support neuronalneurite outgrowth..
EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.