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Mouse ALK-1,ACVRL1 ELISA Kit

EK5716
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  Catalog No. Package Size Price
EK5716 96T $599.00

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Description
  • Product Name Mouse ALK-1,ACVRL1 ELISA Kit
  • Specificity Mouse
  • Crossing Reactivity There is no detectable cross-reactivity with other relevant proteins.
  • Immunogen Type NSO,D23-P119
  • Alternative Names Serine,threonine-protein kinase receptor R3; SKR3; 2.7.11.30; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; Acvrl1; Acvrlk1, Alk-1;
  • Accession No. Q61288
  • Cell Localization Cell membrane; Single-pass type I membraneprotein.
Application Details

sensitivity:15pg ml
Detect Range:46.9pg ml-3000pg ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
capture_antibody:
detection_antibody:
gene_name:Acvrl1
protein_name:Serine threonine-protein kinase receptor R3
gene_full_name:Serine threonine-protein kinase receptor R3
tissue_specificity:
sequence_similarities:
tmb_incubation:25-30min
research_category:cardiovascular|angiogenesis|growth factors|tgf|signal transduction|metabolism|amino acids|protein phosphorylation|ser / thr kinases kinases|growth factors/hormones|vasculature|endothelium|pathways and processes|metabolic signaling pathways|amino acid metabolism|types of disease|cancer

Product Description
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse ALK-1,ACVRL1
Background
protein_function: Type I receptor for TGF-beta family ligands BMP9,GDF2and BMP10 and important regulator of normal blood vesseldevelopment. On ligand binding, forms a receptor complexconsisting of two type II and two type I transmembraneserine,threonine kinases. Type II receptors phosphorylate andactivate type I receptors which autophosphorylate, then bind andactivate SMAD transcriptional regulators. May bind activin aswell..
Serine,threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine,threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
    Please let us know if you have published research using #EK5716 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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