protein_function: Extracellular matrix and cell adhesion protein thatplays a role in nervous system development and in synapticplasticity. Both soluble and membranous forms promote neuriteoutgrowth of cerebellar and hippocampal neurons and suppressneuronal cell death. Plays a role in neuronal positioning ofpyramidal neurons and in regulation of both the number ofinterneurons and the efficacy of GABAergic synapses. May play arole in regulating cell migration in nerve regeneration andcortical development. Potentiates integrin-dependent cellmigration towards extracellular matrix proteins. Recruits ANK3 tothe plasma membrane (By similarity)..
Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. This protein is a member of the L1 gene family of neural cell adhesion molecules. By FISH, the CHL1 gene was mapped to chromosome 3p26.1. The protein however has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations. This protein may also play a role in the growth of certain cancers.