• Product NameGSK1838705A
• Brief DescriptionInhibitors
• Purification98.89%
• Biological ActivityGSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.
• Target NameALK inhibitor; IGF-1R inhibitor; JNK inhibitor; S6 Kinase inhibitor
• CAS No. 1116235-97-2
• Calculated MW 532.57
• Formulation C27H29FN8O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC(=O)C1=C(NC2=NC(NC3=C(OC)C=C4CCN(C(=O)CN(C)C)C4=C3)=NC3=C2C=CN3)C=CC=C1F
  Pathways:Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:ALK; IGF-1R; Insulin Receptor; JNK3; RSK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 107 mg/mL (200.91 mM)
  Appearance:Khaki Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sabbatini P, et al. Mol Y Ther. 2009, 8(10), 2811-2820.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting