• Product NameMX69
• Brief DescriptionInhibitors
• Purification97.27%
• Biological ActivityMX69 is the?MDM2/XIAP?inhibitor, used for Y treatment. MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to Y cell apoptosis in vitro and inhibition of Y cell proliferation in vivo.
• Target NameMdm2 inhibitor
• CAS No. 1005264-47-0
• Calculated MW 474.57
• Formulation C27H26N2O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cc1cc(ccc1C)NS(=O)(=O)c2ccc3NC(C4CC=CC4c3c2)c5ccc(cc5)C(=O)O
  Pathways:Apoptosis
  Receptor:Mdm2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 95 mg/mL (200.18 mM); Ethanol: 41 mg/mL (86.39 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gu L, et al. Y Cell. 2016, 30(4):623-636.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting