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Cyclin D1 Antibody

48619
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  Catalog No. Package Size Price
48619-1 50ul $260.00
48619-2 100ul $390.00

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Description
  • Product Name Cyclin D1 Antibody
  • Clone No. SA38-08
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC, IP
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names AI327039 antibody
    B cell CLL/lymphoma 1 antibody
    B cell leukemia 1 antibody
    B cell lymphoma 1 protein antibody
    B-cell lymphoma 1 protein antibody
    BCL 1 antibody
    BCL-1 antibody
    BCL-1 oncogene antibody
    BCL1 antibody
    BCL1 oncogene antibody
    ccnd1 antibody
    CCND1/FSTL3 fusion gene, included antibody
    CCND1/IGHG1 fusion gene, included antibody
    CCND1/IGLC1 fusion gene, included antibody
    CCND1/PTH fusion gene, included antibody
    CCND1_HUMAN antibody
    cD1 antibody
    Cyl 1 antibody
    D11S287E antibody
    G1/S specific cyclin D1 antibody
    G1/S-specific cyclin-D1 antibody
    Parathyroid adenomatosis 1 antibody
    PRAD1 antibody
    PRAD1 oncogene antibody
    U21B31 antibody
  • Accession No. Swiss-Prot#:P24385
  • Calculated MW 34 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Images
  • Cyclin D1 Antibody - SAB | Signalway Antibody

    Western blot analysis of Cyclin D1 on different lysates using anti-Cyclin D1 antibody at 1/1,000 dilution. Positive control:
    Lane 1: Hela
    Lane 2: PC-12
    Lane 3: SH-SY-5Y

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-Cyclin D1 antibody. Counter stained with hematoxylin.

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti-Cyclin D1 antibody. Counter stained with hematoxylin.

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Cyclin D1 antibody. Counter stained with hematoxylin.

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cyclin D1 antibody. Counter stained with hematoxylin.

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    ICC staining Cyclin D1 in PC-12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Cyclin D1 Antibody - SAB | Signalway Antibody

    ICC staining Cyclin D1 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Background

The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.

Regerences

1. Totta, P. et al. 2015. Clathrin heavy chain interacts with estrogen receptor α and modulates 17β-estradiol signaling. Molecular endocrinology (Baltimore, Md.). : me20141385.
2. Luo, Y. et al. 2015. Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36: 2937-45.

    Please let us know if you have published research using #48619 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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