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Survivin Antibody

48710
Review: comment rank 5 pdf
  Catalog No. Package Size Price
48710-1 50ul $260.00
48710-2 100ul $390.00

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Description
  • Product Name Survivin Antibody
  • Clone No. SP07-06
  • Purification ProA affinity purified
  • Applications ICC/IF, IHC, FC
  • Species Reactivity Hu
  • Immunogen Description recombinant protein
  • Alternative Names API4 antibody
    Apoptosis inhibitor 4 antibody
    Apoptosis inhibitor survivin antibody
    Apoptosis inhibitor4 antibody
    Baculoviral IAP repeat containing 5 antibody
    Baculoviral IAP repeat containing protein 5 antibody
    Baculoviral IAP repeat-containing protein 5 antibody
    BIRC 5 antibody
    BIRC5 antibody
    BIRC5_HUMAN antibody
    EPR 1 antibody
    IAP4 antibody
    Survivin variant 3 alpha antibody
    SVV antibody
    TIAP antibody
  • Accession No. Swiss-Prot#:O15392
  • Calculated MW 16 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Images
  • Survivin Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Survivin antibody. Counter stained with hematoxylin.

  • Survivin Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Survivin antibody. Counter stained with hematoxylin.

  • Survivin Antibody - SAB | Signalway Antibody

    ICC staining Survivin in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Survivin Antibody - SAB | Signalway Antibody

    Flow cytometric analysis of Hela cells with Survivin antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

Background

The baculovirus protein p35 inhibits virally-induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the immune system of the host. This is accomplished at least in part by the ability of p35 to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.

Regerences

1. Lin Y et al. Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro. Mol Med Rep 13:1026-32 (2016).
2. Cao C et al. The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of ?-catenin in HCC cells. Gastroenterology 148:415-26.e18 (2015).

    Please let us know if you have published research using #48710 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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