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Lamin B1 Antibody

48747
Review: comment rank 5 pdf
  Catalog No. Package Size Price
48747-1 50ul $260.00
48747-2 100ul $390.00

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Description
  • Product Name Lamin B1 Antibody
  • Clone No. SI17-06
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC, IP
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names ADLD antibody
    lamin B1 antibody
    Lamin-B1 antibody
    LMN antibody
    LMN2 antibody
    LMNB antibody
    Lmnb1 antibody
    LMNB1_HUMAN antibody
    MGC111419 antibody
    OTTHUMP00000159218 antibody
  • Accession No. Swiss-Prot#:P20700
  • Calculated MW 70 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000
IHC: 1:100-1:500
ICC: 1:50-1:200

Images
  • Lamin B1 Antibody - SAB | Signalway Antibody

    Western blot analysis of Lamin B1 on different lysates using anti-Lamin B1 antibody at 1/1,000 dilution. Positive control:
    Lane 1: Mouse liver
    Lane 2: Mouse brain

  • Lamin B1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Lamin B1 antibody. Counter stained with hematoxylin.

  • Lamin B1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Lamin B1 antibody. Counter stained with hematoxylin.

  • Lamin B1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Lamin B1 antibody. Counter stained with hematoxylin.

  • Lamin B1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Lamin B1 antibody. Counter stained with hematoxylin.

  • Lamin B1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Lamin B1 antibody. Counter stained with hematoxylin.

Background

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.

Regerences

1. Cruz OH et al. Multinucleation and Polykaryon Formation is Promoted by the EhPC4 Transcription Factor in Entamoeba histolytica. Sci Rep 6:19611 (2016).
2. Lund K et al. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS One 10:e0123684 (2015).

    Please let us know if you have published research using #48747 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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