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Myeloperoxidase Antibody

49434
Review: comment rank 5 pdf
  Catalog No. Package Size Price
49434-1 50ul $260.00
49434-2 100ul $390.00

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Description
  • Product Name Myeloperoxidase Antibody
  • Host Species Rabbit
  • Clonality Monoclonal
  • Clone No. JM10-58
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC
  • Species Reactivity Hu
  • Immunogen Description recombinant protein
  • Alternative Names 84 kDa myeloperoxidase antibody
    89 kDa myeloperoxidase antibody
    EC 1.11.1.7 antibody
    EC1.11.2.2 antibody
    fj80f04 antibody
    MPO antibody
    mpx antibody
    myeloid-specific peroxidase antibody
    Myeloperoxidase antibody
    Myeloperoxidase heavy chain antibody
    Myeloperoxidase light chain antibody
    PERM_HUMAN antibody
    wu:fj80f04 antibody
  • Accession No. Swiss-Prot#:P05164
  • Calculated MW 84 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:50-1:200

Images
  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    Western blot analysis of Myeloperoxidase on HL-60 cell lysates using anti-Myeloperoxidase antibody at 1/1,000 dilution.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Myeloperoxidase antibody. Counter stained with hematoxylin.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Myeloperoxidase antibody. Counter stained with hematoxylin.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Myeloperoxidase antibody. Counter stained with hematoxylin.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Myeloperoxidase antibody. Counter stained with hematoxylin.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    ICC staining Myeloperoxidase in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    ICC staining Myeloperoxidase in MCF-7 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Myeloperoxidase Antibody - SAB | Signalway Antibody

    ICC staining Myeloperoxidase in AGS cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Background
The heme protein myeloperoxidase (MPO) is a major component of azurophilic granules of neutrophils and polymorphonuclear leukocytes. Optimal oxygen-dependent microbiocidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products. The MPO precursor is synthesized during the promyelocytic stage of myeloid differentiation and is subsequently processed and transported intracellularly to the lysosomes. The precursor undergoes cotranslational N-linked glycosylation to produce a glycoprotein. Glucosidases in the endoplasmic reticulum (ER) or early cis Golgi convert the pro-MPO to a form which is sorted into a prelysosomal compartment, which undergoes final proteolytic maturation to native MPO, a pair of heavy-light protomers. In normal neutrophils, MPO is expressed as a dimer. Calreticulin, a calcium-binding protein residing in the ER, interacts specifically with fully glycosylated apopro-MPO. iMPO mRNA is abundant in human promyelocytic HL-60 and mouse myeloid leukemia NFS-60 cells. MPO is expressed at high levels in circulating neutrophils and monocytes but is not detectable in microglia, brain-specific macrophages or normal brain tissue.
Regerences
1. Takahashi H et al. A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors. J Neurosci 36:8210-27 (2016).
2. Arosh JA et al. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc Natl Acad Sci U S A 112:9716-21 (2015).
    Please let us know if you have published research using #49434 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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