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MAP3K7 (Phospho-Thr187) Conjugated Antibody

C11899
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  Catalog No. Package Size Price
C11899-AF350 100ul $379.00
C11899-AF405 100ul $379.00
C11899-AF488 100ul $379.00
C11899-AF594 100ul $379.00
C11899-AF647 100ul $379.00
C11899-AF680 100ul $379.00
C11899-AF750 100ul $399.00
C11899-Biotin 100ul $359.00

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Description
  • Product Name MAP3K7 (Phospho-Thr187) Conjugated Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of IMAP3K7 only when phosphorylated at threonine 187.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of threonine 187 (H-M-T(p)-N-N) derived from Human MAP3K7.
  • Conjugates Biotin AF350 AF405 AF488 AF594 AF647 AF680 AF750
  • Excitation Emission AF350: 346nm/442nm
    AF405: 401nm/421nm
    AF488: 493nm/519nm
    AF594: 591nm/614nm
    AF647: 651nm/667nm
    AF680: 679nm/702nm
    AF750: 749nm/775nm
  • Target Name MAP3K7
  • Modification Phospho
  • Alternative Names M3K7; MAP3K7; Mitogen-activated protein kinase kinase kinase 7; TGF-beta- activated kinase 1; kinase TAK1
  • Accession No. Swiss-Prot#: O43318;
    NCBI Gene#: 6885;
    NCBI Protein#: NP_003179.1
  • SDS-PAGE MW 60kd
  • Concentration
  • Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 10mg/ml Bovine Serum Albumin, 0.05% Sodium Azide
  • Storage Store at 4˚Cin dark for 6 months
Application Details

Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin,most applications: 1: 50 - 1: 1,000

Product Description
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Background

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.

Shin MS, et al. (2009)Biochim Biophys Acta 1793, 1156-64
Liu Q, Busby JC, Molkentin JD (2009)Nat Cell Biol 11, 154-61
Kim SI, Kwak JH, Wang L, Choi ME (2008)J Biol Chem 283, 10753-63

    Please let us know if you have published research using #C11899 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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