• Product NameTau(Ab-404) Conjugated Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous level of total Tau protein.
• Immunogen TypePeptide-KLH
• Immunogen DescriptionPeptide sequence around aa. 402~406 (D-T-S-P-R) derived from Human Tau.
• ConjugatesBiotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation EmissionAF350: 346nm/442nm
  AF405: 401nm/421nm
  AF488: 493nm/519nm
  AF555: 555nm/565nm
  AF594: 591nm/614nm
  AF647: 651nm/667nm
  AF680: 679nm/702nm
  AF750: 749nm/775nm
• Target NameTau
• Alternative Names    Neurofibrillary tangle protein; Paired helical filament-tau;
• Accession No. Swiss-Prot: P10636
  NCBI Protein: NP _001116538.1
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

• Predicted MW: 48 62 78 kd
  Western blotting: 1:500~1:1000
  

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Li G, Yin H, et.al .(2004) J Biol Chem ; 279(16): 15938-45.
Noble W, et al. (2003) Neuron ; 38(4): 555-65.
Giasson BI, et al.(2002). Biochemistry; 41(51): 15376-87.
Lee G., et.al. (1989). Neuron 2:1615-1624.
Andreadis A.et.al. (1992) Biochemistry 31:10626-10633.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting